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Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-linetreatment: a retrospective study of 251 cases

null

《医学前沿（英文）》 2014年 第8卷 第1期   页码 91-95 doi: 10.1007/s11684-014-0305-7

摘要：

A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinico-pathological parameters, including progression-free survival (PFS) and overall survival (OS), were also analyzed. The median follow-up period from the end of initial treatment to June 2010 was 58 months. The three-year PFS rate was 61.7% for International Federation of Gynecology and Obstetrics (FIGO) I–II, 19.9% for FIGO III–IV, and 33.9% for all stages. By comparison, the five-year PFS rate was 44.6% for FIGO I–II, 17.7% for FIGO III–IV, and 28.3% for all stages. The three-year OS rate was 67.9% for FIGO I–II, 41.7% for FIGO III–IV, and 50.2% for all stages. The five-year OS rate was 52.7% for FIGO I–II, 30.8% for FIGO III–IV, and 39.2% for all stages. Univariate analysis revealed that advanced FIGO stage, serum CA125, and suboptimal debulking were significant factors affecting PFS and OS. In multivariate analysis, PFS was significantly influenced by FIGO stage and suboptimal debulking. However, OS was significantly influenced by advanced FIGO stage only. Our study confirms the efficacy of surgery followed by platinum-based chemotherapy for EOC. FIGO stage is considered as one of the most reliable predictors of the prognosis of patients with EOC.

关键词： ovarian carcinoma     prognostic factors     surgery     chemotherapy     survival    

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Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in

WANG Zhiqiang

《医学前沿（英文）》 2008年 第2卷 第2期   页码 171-173 doi: 10.1007/s11684-008-0031-0

摘要： This study aimed to investigate the treatment outcomes of esophageal variceal bleeding (EVB) in China. A total of 1087 cases were collected from 19 hospitals in 16 large and medium sized cities across China between January 1st, 2005 and January 1st, 2006. There were 313 cases (29.0%) of mild (<400 mL), 494 cases (45.8%) of moderate (400–1500 mL) and 272 cases (25.2%) of severe (>1500 mL) bleeding. Successful hemostasis was achieved in 89.8% of cases. Seven hundred and eighty-five cases were treated by medication with a hemostasis rate of 91.8%. Seventy-one cases were treated using a Sengstaken-Blakemore tube with a hemostasis rate of 54.9%. Thirty-seven cases were treated with emergency endoscopic variceal ligation with a hemostasis rate of 83.8%. Seventy-seven cases were treated with endoscopic sclerotherapy with a hemostasis rate of 94.8%. Forty-three cases were treated with emergency surgical operation with a hemostasis rate of 95.3%. Sixty-six cases were treated with combined therapy with a hemostasis rate of 97.0%. There was a significant difference ( < 0.01) in the successful hemostasis rate between different treatments. The overall mortality was 10.1%, among which 6.6% was directly caused by bleeding. The multivariate logistic regression analysis shows that the severity of bleeding, treatment methods, liver dysfunction and activation of hepatitis were predictive factors for successful hemostasis. Most cases of EVB were mild and moderate in severity. The first-line treatment for EVB is medication. Emergency endoscopic intervention has not been widely available yet. The overall management outcome of EVB has been improved.

关键词： significant difference     predictive     medication     first-line treatment     bleeding    

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南水北调中线一期工程

钮新强

《工程（英文）》 2022年 第16卷 第9期   页码 21-28 doi: 10.1016/j.eng.2022.07.001

关键词： 工程成就    

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Electrocoagulation process for the treatment of metal-plating wastewater: Kinetic modeling and energy

Fatih Ilhan, Kubra Ulucan-Altuntas, Yasar Avsar, Ugur Kurt, Arslan Saral

《环境科学与工程前沿（英文）》 2019年 第13卷 第5期 doi: 10.1007/s11783-019-1152-1

摘要： The wastewater from industrial area was treated by EC via Fe and Al electrodes. Cu, Ni, Cr and Zn were highly removed at the first minutes, simultaneously. Pseudo-2nd-order was found to be more suitable for kinetics. Adsorption capacities based on kinetic modeling were observed as Cr>Cu>Ni>Zn. The chemical cost in the case of pH adjustment after EC was less as 3.83 $/m3. It is known that wastewater produced by the metal-plating industry contains several heavy metals, which are acidic in nature and therefore toxic for the environment and for living creatures. In particular, heavy metals enter the food chain and accumulate in vital organs and cause serious illness. The precipitation of these metals is mostly achieved by pH adjustment, but as an alternative to this method, the electrocoagulation process has investigated in this study using iron and aluminum electrodes. The effects of the pH adjustment on removal before and after the electrocoagulation process were investigated, and cost analyses were also compared. It was observed that a high proportion of removal was obtained during the first minutes of the electrocoagulation process; thus, the current density did not have a great effect. In addition, the pH adjustment after the electrocoagulation process using iron electrodes, which are 10% more effective than aluminum electrodes, was found to be much more efficient than before the electrocoagulation process. In the process where kinetic modeling was applied, it was observed that the heavy metal removal mechanism was not solely due to the collapse of heavy metals at high pH values, and with this modeling, it was seen that this mechanism involved adsorption by iron and aluminum hydroxides formed during the electrocoagulation process. When comparing the ability of heavy metals to be adsorbed, the sequence was observed to be Cr>Cu>Ni>Zn, respectively.

关键词： Electrochemical treatment     Heavy metals     Kinetic modeling     Pseudo first order kinetic     Pseudo second order kinetic    

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China Launched the First Wastewater Resource Recovery Factory in Yixing

《环境科学与工程前沿（英文）》 2022年 第16卷 第1期 doi: 10.1007/s11783-021-1496-1

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Sustainable intensification of agriculture in sub-Saharan Africa: first things first!

Bernard VANLAUWE, Achim DOBERMANN

《农业科学与工程前沿（英文）》 2020年 第7卷 第4期   页码 376-382 doi: 10.15302/J-FASE-2020351

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Acoustic fault signal extraction via the line-defect phononic crystals

《机械工程前沿（英文）》 2022年 第17卷 第1期   页码 10-10 doi: 10.1007/s11465-021-0666-y

摘要： Rotating machine fault signal extraction becomes increasingly important in practical engineering applications. However, fault signals with low signal-to-noise ratios (SNRs) are difficult to extract, especially at the early stage of fault diagnosis. In this paper, 2D line-defect phononic crystals (PCs) consisting of periodic acrylic tubes with slit are proposed for weak signal detection. The defect band, namely, the formed resonance band of line-defect PCs enables the incident acoustic wave at the resonance frequency to be trapped and enhanced at the resonance cavity. The noise can be filtered by the band gap. As a result, fault signals with high SNRs can be obtained for fault feature extraction. The effectiveness of weak harmonic and periodic impulse signal detection via line-defect PCs are investigated in numerical and experimental studies. All the numerical and experimental results indicate that line-defect PCs can be well used for extracting weak harmonic and periodic impulse signals. This work will provide potential for extracting weak signals in many practical engineering applications.

关键词： phononic crystals     line-defect     fault signal extraction     acoustic enhancement    

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Sensitivity of supplementation of thyroid hormone on treatment of idiopathic short-stature children during

Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng

《医学前沿（英文）》 2018年 第12卷 第5期   页码 580-585 doi: 10.1007/s11684-017-0585-9

摘要：

This study aimed to evaluate the effects of thyroid hormone supplementation on growth rate of children with idiopathic short stature (ISS) and low-normal serum free thyroxine FT4 who were receiving growth hormone therapy. We selected 64 prepubertal children with FT4 levels in the lowest third of the normal range as the lower FT4 group, and these children were divided randomly into two subgroups: L-thyroxine (L-T4)-treated subgroup was treated with L-T4 (0.5–3.0 g/(kg·d)) from the beginning of the study, and the non-L-T4-treated subgroup received placebo. We also selected 39 ISS children with FT4 in the upper two-thirds of the normal range as the higher FT4 group. During the first year, the lower FT4 group featured lower FT3, FT4, thyroid stimulating hormone (TSH), and insulin-like growth factor-I standard deviation score (IGF-I SDS) and significantly lower height velocity (HV) compared with the higher FT4 group. However, in the lower FT4 group, the L-T4-treated subgroup presented higher FT4, FT3, TSH, and IGF-I SDS concentrations and significantly higher HV compared with children in the non-L-T4-treated subgroup. In children with ISS, the negative effect of thyroid hormone deficiency on growth rate should be considered when FT4 level lies in the low-normal range prior to recombinant human growth hormone treatment.

关键词： therapeutic     idiopathic short-stature children     free T4     the first year     recombinant human growth hormone    

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Calculations of narrow-band transimissities and the Planck mean absorption coefficients of real gases using line-by-line

Huaqiang CHU, Mingyan GU, Huaichun ZHOU, Fengshan LIU

《能源前沿（英文）》 2014年 第8卷 第1期   页码 41-48 doi: 10.1007/s11708-013-0292-4

摘要： Narrow-band transmissivities in the spectral range of 150 to 9300 cm and at a uniform resolution of 25 cm were calculated using the statistical narrow-band (SNB) model with the band parameters of Soufiani and Taine, the more recent parameters of André and Vaillon, and the line-by-line (LBL) method along with the HITEMP-2010 spectroscopic database. Calculations of narrow-band transmissivity were conducted for gas columns of different lengths and containing different isothermal and non-isothermal CO -H O-N mixtures at 1 atm. Narrow-band transmissivities calculated by the SNB model are in large relative error at many bands. The more recent SNB model parameters of André and Vaillon are more accurate than the earlier parameters of Soufiani and Taine. The Planck mean absorption coefficients of CO , H O, CO, and CH in the temperature range of 300 to 2500 K were calculated using the LBL method and different versions of the high resolution transmission (HITRAN) and high-temperature spectroscopic absorption parameters (HITEMP) spectroscopic databases. The SNB model was also used to calculate the Planck mean absorption coefficients of these four radiating gases. The LBL results of the Planck mean absorption coefficient were compared with the classical results of Tien and those from the SNB model.

关键词： transimissity     HITEMP     HITRAN     Planck mean absorption coefficients    

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Ammonia adsorption on graphene and graphene oxide: a first-principles study

Yue PENG, Junhua LI

《环境科学与工程前沿（英文）》 2013年 第7卷 第3期   页码 403-411 doi: 10.1007/s11783-013-0491-6

摘要： Motivated by the recent realization of graphene sensor to detect gas molecules that are harmful to the environment, the ammonia adsorption on graphene or graphene oxide (GO) was investigated using first-principles calculation. The optimal adsorption and orientation of the NH molecules on the graphene surfaces were determined, and the adsorption energies ( ) as well as the Mulliken charge transfers of NH were calculated. The for the graphene are small and seem to be independent of the sites and orientations. The surface epoxy or hydroxyl groups can promote the adsorption of NH on the GO; the enhancement of the for the hydroxyl groups is greater than that for the epoxy groups on the surface. The charge transfers from the molecule to the surfaces also exhibit the same trend. The Br?nsted acid sites and Lewis acid sites could stably exist on the GO with surface hydroxyl groups and on the basal, respectively.

关键词： graphene oxide     first-principles calculations     NH3 adsorption    

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Pareto lexicographic α-robust approach and its application in robust multi objective assembly line balancing

null

《机械工程前沿（英文）》 2014年 第9卷 第3期   页码 257-264 doi: 10.1007/s11465-014-0294-x

摘要：

Robustness in most of the literature is associated with min-max or min-max regret criteria. However, these criteria of robustness are conservative and therefore recently new criteria called, lexicographic α-robust method has been introduced in literature which defines the robust solution as a set of solutions whose quality or jth largest cost is not worse than the best possible jth largest cost in all scenarios. These criteria might be significant for robust optimization of single objective optimization problems. However, in real optimization problems, two or more than two conflicting objectives are desired to optimize concurrently and solution of multi objective optimization problems exists in the form of a set of solutions called Pareto solutions and from these solutions it might be difficult to decide which Pareto solution can satisfy min-max, min-max regret or lexicographic α-robust criteria by considering multiple objectives simultaneously. Therefore, lexicographic α-robust method which is a recently introduced method in literature is extended in the current research for Pareto solutions. The proposed method called Pareto lexicographic α-robust approach can define Pareto lexicographic α-robust solutions from different scenarios by considering multiple objectives simultaneously. A simple example and an application of the proposed method on a simple problem of multi objective optimization of simple assembly line balancing problem with task time uncertainty is presented to get their robust solutions. The presented method can be significant to implement on different multi objective robust optimization problems containing uncertainty.

关键词： Pareto     lexicographic α-robust     assembly line balancing    

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The First Attempt for Accounts of Environmental Chemistry and Technology Research

Jinyong Liu, Yin Wang, Haoran Wei

《环境科学与工程前沿（英文）》 2020年 第14卷 第5期 doi: 10.1007/s11783-020-1270-9

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Choosing configurations of transmission line tower grounding by back flashover probability value

Dmitry KUKLIN

《能源前沿（英文）》 2016年 第10卷 第2期   页码 213-226 doi: 10.1007/s11708-016-0398-6

摘要： There is a considerable number of works devoted to electrical characteristics of grounding. These characteristics are important in general. However, in application to grounding of transmission line towers they are not enough to determine what grounding construction is preferable in some particular case, because these characteristics are calculated or measured apart from the grounded object, and only limited number of current (or voltage) source waveforms is used. This paper indicates reasons in favor of the fact that to choose the optimum design of grounding, the calculation model should include the tower as it is. The probability of back flashover, which provides both qualitative and quantitative estimate of the grounding structure efficiency, can be taken as the criterion for the grounding design. The insulation flashover probability is calculated on the basis of engineering method, which evaluates breakdown strength of insulation for nonstandard waveshapes, and probability data on lightning currents. Different approaches are examined for identifying the back flashover probability, as not only amplitudes but also other parameters can be taken into account. Finite-difference time-domain method is used for calculations of transients. It is found that lightning current waveform can greatly influence calculated back flashover probability value.

关键词： grounding     transmission line tower     back flashover probability     FDTD method    

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A fast compound direct iterative algorithm for solving transient line contact elastohydrodynamic lubrication

null

《机械工程前沿（英文）》 2014年 第9卷 第2期   页码 156-167 doi: 10.1007/s11465-014-0297-7

摘要：

A fast compound direct iterative algorithm for solving transient line contact elastohydrodynamic lubrication (EHL) problems is presented. First, by introducing a special matrix splitting iteration method into the traditional compound direct iterative method, the full matrices for the linear systems of equations are transformed into sparse banded ones with any half-bandwidth; then, an extended Thomas method which can solve banded linear systems with any half-bandwidth is derived to accelerate the computing speed. Through the above two steps, the computational complexity of each iteration is reduced approximately from O(N3/3) to O(β2N), where N is the total number of nodes, and β is the half-bandwidth. Two kinds of numerical results of transient EHL line contact problems under sinusoidal excitation or pure normal approach process are obtained. The results demonstrate that the new algorithm increases computing speed several times more than the traditional compound direct iterative method with the same numerical precision. Also the results show that the new algorithm can get the best computing speed and robustness when the ratio, half-bandwidth to total number of nodes, is about 7.5%–10.0% in moderate load cases.

关键词： elastohydrodynamic lubrication     transient     line contact     matrix splitting iteration method     the Thomas method    

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Modified landfill gas generation rate model of first-order kinetics and two-stage reaction

Jiajun CHEN , Hao WANG , Na ZHANG ,

《环境科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 313-319 doi: 10.1007/s11783-009-0025-4

摘要： This investigation was carried out to establish a new domestic landfill gas (LFG) generation rate model that takes into account the impact of leachate recirculation. The first-order kinetics and two-stage reaction (FKTSR) model of the LFG generation rate includes mechanisms of the nutrient balance for biochemical reaction in two main stages. In this study, the FKTSR model was modified by the introduction of the outflow function and the organic acid conversion coefficient in order to represent the in-situ condition of nutrient loss through leachate. Laboratory experiments were carried out to simulate the impact of leachate recirculation and verify the modified FKTSR model. The model calibration was then calculated by using the experimental data. The results suggested that the new model was in line with the experimental data. The main parameters of the modified FKTSR model, including the LFG production potential (), the reaction rate constant in the first stage (), and the reaction rate constant in the second stage () of 64.746 L, 0.202 d, and 0.338 d, respectively, were comparable to the old ones of 42.069 L, 0.231 d, and 0.231 d. The new model is better able to explain the mechanisms involved in LFG generation.

关键词： landfill gas (LFG)     generation rate model     first-order kinetics     two-stage reaction     outflow function    

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标题 作者 时间 类型 操作

Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-linetreatment: a retrospective study of 251 cases

null

期刊论文

Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in

WANG Zhiqiang

期刊论文

南水北调中线一期工程

钮新强

期刊论文

Electrocoagulation process for the treatment of metal-plating wastewater: Kinetic modeling and energy

Fatih Ilhan, Kubra Ulucan-Altuntas, Yasar Avsar, Ugur Kurt, Arslan Saral

期刊论文

China Launched the First Wastewater Resource Recovery Factory in Yixing

期刊论文

Sustainable intensification of agriculture in sub-Saharan Africa: first things first!

Bernard VANLAUWE, Achim DOBERMANN

期刊论文

Acoustic fault signal extraction via the line-defect phononic crystals

期刊论文

Sensitivity of supplementation of thyroid hormone on treatment of idiopathic short-stature children during

Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng

期刊论文

Calculations of narrow-band transimissities and the Planck mean absorption coefficients of real gases using line-by-line

Huaqiang CHU, Mingyan GU, Huaichun ZHOU, Fengshan LIU

期刊论文

Ammonia adsorption on graphene and graphene oxide: a first-principles study

Yue PENG, Junhua LI

期刊论文

Pareto lexicographic α-robust approach and its application in robust multi objective assembly line balancing

null

期刊论文

The First Attempt for Accounts of Environmental Chemistry and Technology Research

Jinyong Liu, Yin Wang, Haoran Wei

期刊论文

Choosing configurations of transmission line tower grounding by back flashover probability value

Dmitry KUKLIN

期刊论文

A fast compound direct iterative algorithm for solving transient line contact elastohydrodynamic lubrication

null

期刊论文

Modified landfill gas generation rate model of first-order kinetics and two-stage reaction

Jiajun CHEN , Hao WANG , Na ZHANG ,

期刊论文